| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase kinase 1 |
|---|
| Ligand | BDBM591168 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | HPK1-FL HTRF Enzymatic Assay |
|---|
| Ki | 0.021±n/a nM |
|---|
| Citation |  Chan, B; Drobnick, J; Gazzard, L; Heffron, T; Liang, J; Malhotra, S; Mendonca, R; Rajapaksa, N; Stivala, C; Tellis, J; Wang, W; Wei, B; Zhou, A; Cartwright, MW; Lainchbury, M; Gancia, E; Seward, E; Madin, A; Favor, D; Fong, KC; Hu, Y; Good, A Isoquinolines as inhibitors of HPK1 US Patent US11566003 Publication Date 1/31/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase kinase kinase kinase 1 |
|---|
| Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
|---|
| Synonyms: | HPK1 | M4K1_HUMAN | MAP4K1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 91316.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_586597 |
|---|
| Residue: | 833 |
|---|
| Sequence: | MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
|
|
|
|---|
| BDBM591168 |
|---|
| n/a |
|---|
| Name | BDBM591168 |
|---|
| Synonyms: | 2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fluoroisoquinolin- 3-yl)amino)-5,5-dimethyl-5,6-dihydro- 4H-pyrazolo[1,5-d][1,4]diazepin-7(8H)- one | US11566003, Compound 234 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H25FN8O |
|---|
| Mol. Mass. | 460.5067 |
|---|
| SMILES | Cc1c(N)cncc1-c1cc2cc(Nc3cc4CC(C)(C)NC(=O)Cn4n3)ncc2c(N)c1F |
|---|
| Structure | 
|
|---|
Search and Browse
