| Reaction Details |
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 | Report a problem with these data |
| Target | DNA-directed RNA polymerase subunit beta' |
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| Ligand | BDBM592137 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 1500±n/a nM |
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| Citation |  Ebright, RH; Ebright, YW; Freundlich, JS; Gallardo-Macias, R; Li, S Antibacterial agents: arylalkylcarboxamido phloroglucinols US Patent US11572337 Publication Date 2/7/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA-directed RNA polymerase subunit beta' |
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| Name: | DNA-directed RNA polymerase subunit beta' |
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| Synonyms: | RNA polymerase subunit beta' | RNAP subunit beta' | RPOC_STAAU | Transcriptase subunit beta' | rpoC |
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| Type: | Protein |
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| Mol. Mass.: | 118610.70 |
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| Organism: | n/a |
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| Description: | P0C1T4 |
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| Residue: | 1057 |
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| Sequence: | MIDVNNFHYMKIGLASPEKIRSWSFGEVKKPETINYRTLKPEKDGLFCERIFGPTKDWEC
SCGKYKRVRYKGMVCDRCGVEVTKSKVRRERMGHIELAAPVSHIWYFKGIPSRMGLLLDM
SPRALEEVIYFASYVVVDPGPTGLEKKTLLSEAEFRDYYDKYPGQFVAKMGAEGIKDLLE
EIDLDEELKLLRDELESATGQRLTRAIKRLEVVESFRNSGNKPSWMILDVLPIIPPEIRP
MAQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPGIIVQNEKRMLQEAVDALIDNGR
RGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIAVGPSLKMYQCGLPKE
MALELFKPFVMKELVQREIATNIKNAKSKIERMDDEVWDVLEEVIREHPVLLNRAPTLHR
LGIQAFEPTLVEGRAIRLHPLVTTAYNADFDGDQMAVHVPLSKEAQAEARMLMLAAQNIL
NPKDGKPVVTPSQDMVLGNYYLTLERKDAVNTGAIFNNTNEVLKAYANGFVHLHTRIGVH
ASSFNNPTFTEEQNKKILATSVGKIIFNEIIPDSFAYINEPTQENLERKTPNRNFIDPTT
LGEGGLKEYFENEELIEPFNKKFLGNIIAEVFNRFSITDTSMMLDRMKDLGFKFSSKAGI
TVGVADIVVLPDKQQILDEHEKLVDRITKQFNRGLITEEERYNAVVEIWTDAKDQIQGEL
MQSLDKTNPIFMMSDSGARGNASNFTQLAGMRGLMAAPSGKIIELPITSSFREGLTVLEY
FISTHGARKGLADTALKTADSGYLTRRLVDVAQDVIVREEDCGTDRGLLVSDIKEGTEMI
EPFIERIEGRYSKETIRHPETDEIIIRPDELITPEIAKKITDAGIEQMYIRSAFTCNARH
GVCEKCYGKNLATGEKVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVAGSDITQGLPRI
QEIFEARNPKGQAVITEIEGVVEDIKLAKDRQQEIVVKGANETRSYLASGTSRIIVEIGQ
PVQRGEVLTEGSIEPKNYLSVAGLNATESYLLKEVQK
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| BDBM592137 |
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| n/a |
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| Name | BDBM592137 |
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| Synonyms: | US11572337, Compound 0MTK149 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17NO5 |
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| Mol. Mass. | 351.3527 |
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| SMILES | Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccccc3)cc2)c(O)c1 |
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| Structure | 
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