Reaction Details |
| Report a problem with these data |
Target | Histone deacetylase 6 |
---|
Ligand | BDBM593576 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Biochemical Assay |
---|
IC50 | 13.0±n/a nM |
---|
Citation | Patel, S; Mandegar, MA; Sperandio, D; Medina, J; Bhatt, U; Nerurkar, A; Widjaja, T Fluoroalkyl-oxadiazoles and uses thereof US Patent US11578066 Publication Date 2/14/2023 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histone deacetylase 6 |
---|
Name: | Histone deacetylase 6 |
Synonyms: | Cereblon/Histone deacetylase 6 | HD6 | HDAC6 | HDAC6_HUMAN | Histone deacetylase 6 (HDAC6) | Human HDAC6 | KIAA0901 | ORF Names:JM21 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 131381.51 |
Organism: | Homo sapiens (Human) |
Description: | Q9UBN7 |
Residue: | 1215 |
Sequence: | MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLG
QAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLI
QEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNS
YSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQ
KHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQG
QGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATP
AGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSA
QASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSR
TGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCH
SAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLN
GAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMF
EDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWH
RLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEG
GYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVE
DREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSET
AVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGA
ILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQ
TPLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEA
AGGQDMADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQ
ENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKN
IAHQNKFGEDMPHPH
|
|
|
BDBM593576 |
---|
n/a |
---|
Name | BDBM593576 |
Synonyms: | 3-[({5-[5-(difluoromethyl)-1,3,4-oxadiazol-2- yl]-1,3-thiazol-2-yl}methyl)(pyridin-3- yl)sulfamoyl]propanamide | US11578066, Compound I-268 | US20230381148, Compound I-268 |
Type | Small organic molecule |
Emp. Form. | C15H14F2N6O4S2 |
Mol. Mass. | 444.436 |
SMILES | NC(=O)CCS(=O)(=O)N(Cc1ncc(s1)-c1nnc(o1)C(F)F)c1cccnc1 |
Structure |
|