| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol kinase alpha [9-727] |
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| Ligand | BDBM594248 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro DGK Inhibition Assay |
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| IC50 | 7.00±n/a nM |
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| Citation |  Velaparthi, U; Olson, RE; Darne, CP; Dasgupta, B; Warrier, JS; Rahaman, H; Jalagam, PR; Roy, S; Grunenfelder, DC Substituted pyridopyrimidinonyl compounds useful as T cell activators US Patent US11584747 Publication Date 2/21/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol kinase alpha [9-727] |
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| Name: | Diacylglycerol kinase alpha [9-727] |
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| Synonyms: | DAGK | DAGK1 | DGKA | DGKA_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 80817.73 |
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| Organism: | Homo sapiens |
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| Description: | P23743 [9-727] |
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| Residue: | 719 |
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| Sequence: | SPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIYLEVDNVPR
HLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNG
ILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTV
PLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAM
KALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIH
DDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRI
DPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSR
ILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKD
LEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKF
NSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGG
SNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQI
YTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRS
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| BDBM594248 |
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| n/a |
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| Name | BDBM594248 |
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| Synonyms: | US11584747, Example 42 | US11584747, Example 43 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H32F3N7O3 |
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| Mol. Mass. | 607.6261 |
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| SMILES | CC[C@@H]1CN([C@@H](CC)CN1C(c1cc(on1)C1CC1)c1ccc(OC(F)(F)F)cc1)c1nc(=O)n(C)c2ccc(nc12)C#N |r| |
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| Structure | 
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