| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Diacylglycerol kinase alpha [9-727] |
|---|
| Ligand | BDBM594400 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro DGK Inhibition Assay |
|---|
| IC50 | 12.0±n/a nM |
|---|
| Citation |  Velaparthi, U; Olson, RE; Darne, CP; Dasgupta, B; Warrier, JS; Rahaman, H; Jalagam, PR; Roy, S; Grunenfelder, DC Substituted pyridopyrimidinonyl compounds useful as T cell activators US Patent US11584747 Publication Date 2/21/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Diacylglycerol kinase alpha [9-727] |
|---|
| Name: | Diacylglycerol kinase alpha [9-727] |
|---|
| Synonyms: | DAGK | DAGK1 | DGKA | DGKA_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 80817.73 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | P23743 [9-727] |
|---|
| Residue: | 719 |
|---|
| Sequence: | SPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIYLEVDNVPR
HLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNG
ILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTV
PLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAM
KALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIH
DDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRI
DPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSR
ILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKD
LEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKF
NSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGG
SNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQI
YTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRS
|
|
|
|---|
| BDBM594400 |
|---|
| n/a |
|---|
| Name | BDBM594400 |
|---|
| Synonyms: | US11584747, Example 200 | US11584747, Example 201 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H36N6O |
|---|
| Mol. Mass. | 484.6357 |
|---|
| SMILES | CCC(N1C[C@H](CC)N(C[C@H]1CC)c1nc(=O)n(C)c2ccc(nc12)C#N)c1ccc(cc1)C1CC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
