Reaction Details |
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Target | Diacylglycerol kinase zeta |
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Ligand | BDBM594400 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro DGK Inhibition Assay |
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IC50 | 13.0±n/a nM |
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Citation | Velaparthi, U; Olson, RE; Darne, CP; Dasgupta, B; Warrier, JS; Rahaman, H; Jalagam, PR; Roy, S; Grunenfelder, DC Substituted pyridopyrimidinonyl compounds useful as T cell activators US Patent US11584747 Publication Date 2/21/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Diacylglycerol kinase zeta |
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Name: | Diacylglycerol kinase zeta |
Synonyms: | 2.7.1.107 | DAG kinase zeta | DAGK6 | DGK-zeta | DGKZ | DGKZ_HUMAN | Diacylglycerol kinase zeta | Diglyceride kinase zeta |
Type: | PROTEIN |
Mol. Mass.: | 124177.85 |
Organism: | Homo sapiens |
Description: | ChEMBL_117547 |
Residue: | 1117 |
Sequence: | METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCL
LSCGVRAQGSSRRRSSTVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEE
GVQEDVVAEASSAIQPGTKTPGPPPPRGAQPLLPLPRYLRRASSHLLPADAVYDHALWGL
HGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQVALRRKAAGPQAWSA
LLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCY
VGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVR
HHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCS
LGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSP
LMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILAC
GGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEG
NVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANP
EKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIP
RYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTT
SKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRV
SMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKL
SPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLP
TSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAV
STGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQG
DTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
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BDBM594400 |
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n/a |
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Name | BDBM594400 |
Synonyms: | US11584747, Example 200 | US11584747, Example 201 |
Type | Small organic molecule |
Emp. Form. | C29H36N6O |
Mol. Mass. | 484.6357 |
SMILES | CCC(N1C[C@H](CC)N(C[C@H]1CC)c1nc(=O)n(C)c2ccc(nc12)C#N)c1ccc(cc1)C1CC1 |r| |
Structure |
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