Reaction Details |
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Target | Diacylglycerol kinase alpha [9-727] |
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Ligand | BDBM594504 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro DGK Inhibition Assay |
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IC50 | 13.0±n/a nM |
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Citation | Velaparthi, U; Olson, RE; Darne, CP; Dasgupta, B; Warrier, JS; Rahaman, H; Jalagam, PR; Roy, S; Grunenfelder, DC Substituted pyridopyrimidinonyl compounds useful as T cell activators US Patent US11584747 Publication Date 2/21/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Diacylglycerol kinase alpha [9-727] |
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Name: | Diacylglycerol kinase alpha [9-727] |
Synonyms: | DAGK | DAGK1 | DGKA | DGKA_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 80817.73 |
Organism: | Homo sapiens |
Description: | P23743 [9-727] |
Residue: | 719 |
Sequence: | SPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIYLEVDNVPR
HLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNG
ILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTV
PLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAM
KALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIH
DDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRI
DPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSR
ILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKD
LEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKF
NSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGG
SNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQI
YTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRS
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BDBM594504 |
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n/a |
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Name | BDBM594504 |
Synonyms: | US11584747, Example 311 | US11584747, Example 312 |
Type | Small organic molecule |
Emp. Form. | C28H34N6O2 |
Mol. Mass. | 486.6086 |
SMILES | CCC(N1C[C@H](C)N(C[C@H]1CC)c1nc(=O)n(C)c2ccc(nc12)C#N)c1ccc(OC2CC2)cc1 |r| |
Structure |
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