| Reaction Details |
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 | Report a problem with these data |
| Target | Rho-associated protein kinase 1 [1-535] |
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| Ligand | BDBM598531 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Determination of Compound's ROCK Inhibitory Activity In Vitro (Z'Lyte Assay) |
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| IC50 | 135±n/a nM |
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| Citation |  Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R Inhibitors of RHO associated coiled-coil containing protein kinase US Patent US11613531 Publication Date 3/28/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Rho-associated protein kinase 1 [1-535] |
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| Name: | Rho-associated protein kinase 1 [1-535] |
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| Synonyms: | ROCK1 | ROCK1_HUMAN | Rho-associated protein kinase 1 (ROCK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 62220.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 1-535 |
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| Residue: | 535 |
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| Sequence: | MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA
DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
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| BDBM598531 |
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| n/a |
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| Name | BDBM598531 |
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| Synonyms: | 2-(3-methyl-1,4-diazepan-1-yl)-N-(4-(pyridin-4-yl)phenyl)pyrimidin-4-amine | US11613531, Example 43 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N6 |
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| Mol. Mass. | 360.4555 |
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| SMILES | CC1CN(CCCN1)c1nccc(Nc2ccc(cc2)-c2ccncc2)n1 |
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| Structure | 
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