| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Palmitoleoyl-protein carboxylesterase NOTUM |
|---|
| Ligand | BDBM600938 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Notum Enzymatic Activity Assay |
|---|
| IC50 | 31.6±n/a nM |
|---|
| Citation |  Fish, PV; Mahy, W; Willis, NJ; Woodward, H; Atkinson, BN; Bayle, ED; Sipthorp, J; Jones, EY; Zhao, Y; Vecchia, L; Ruza, RR Compounds which are inhibitors of Notum US Patent US11634391 Publication Date 4/25/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Palmitoleoyl-protein carboxylesterase NOTUM |
|---|
| Name: | Palmitoleoyl-protein carboxylesterase NOTUM |
|---|
| Synonyms: | NOTUM | NOTUM_HUMAN | Palmitoleoyl-protein carboxylesterase NOTUM | hNOTUM |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 55706.36 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_116492 |
|---|
| Residue: | 496 |
|---|
| Sequence: | MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVE
GNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRW
LLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFI
PYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLL
NVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNG
VVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGL
RLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHD
SHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQP
QGLEPSELLGMLSNGS
|
|
|
|---|
| BDBM600938 |
|---|
| n/a |
|---|
| Name | BDBM600938 |
|---|
| Synonyms: | 2-[3-cyclopropyl-4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole | US11634391, Compound 189 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H9F3N2O |
|---|
| Mol. Mass. | 254.2079 |
|---|
| SMILES | FC(F)(F)c1ccc(cc1C1CC1)-c1nnco1 |
|---|
| Structure | 
|
|---|
Search and Browse
