| Reaction Details |
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 | Report a problem with these data |
| Target | Palmitoleoyl-protein carboxylesterase NOTUM |
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| Ligand | BDBM601041 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Notum Enzymatic Activity Assay |
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| IC50 | 30.3±n/a nM |
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| Citation |  Fish, PV; Mahy, W; Willis, NJ; Woodward, H; Atkinson, BN; Bayle, ED; Sipthorp, J; Jones, EY; Zhao, Y; Vecchia, L; Ruza, RR Compounds which are inhibitors of Notum US Patent US11634391 Publication Date 4/25/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Palmitoleoyl-protein carboxylesterase NOTUM |
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| Name: | Palmitoleoyl-protein carboxylesterase NOTUM |
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| Synonyms: | NOTUM | NOTUM_HUMAN | Palmitoleoyl-protein carboxylesterase NOTUM | hNOTUM |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55706.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116492 |
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| Residue: | 496 |
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| Sequence: | MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVE
GNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRW
LLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFI
PYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLL
NVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNG
VVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGL
RLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHD
SHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQP
QGLEPSELLGMLSNGS
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| BDBM601041 |
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| n/a |
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| Name | BDBM601041 |
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| Synonyms: | 1-[2,4-dichloro-3-(trifluoromethyl)phenyl]triazole-4-carboxylic acid | US11634391, Compound 304 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H6Cl2F3N3O2 |
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| Mol. Mass. | 340.085 |
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| SMILES | COC(=O)c1cn(nn1)-c1ccc(Cl)c(c1Cl)C(F)(F)F |
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| Structure | 
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