| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 2 |
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| Ligand | BDBM603953 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioligand Binding Assay |
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| Ki | 11.7±n/a nM |
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| Citation |  Ametamey, SM; Atz, K; Gobbi, L; Grether, U; Guba, W; Kretz, J Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists US Patent US11655243 Publication Date 5/23/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 2 |
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| Name: | Cannabinoid receptor 2 |
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| Synonyms: | CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 39690.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34972 |
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| Residue: | 360 |
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| Sequence: | MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
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| BDBM603953 |
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| n/a |
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| Name | BDBM603953 |
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| Synonyms: | (Rac)-trans-3-fluoropropyl 2-ethyl-2-[[6-[[-2-(hydroxymethyl)cyclopropyl]methoxy]-5-[3-(p-tolylsulfonyloxy)azetidin-1-yl]pyridine-2-carbonyl]amino]butanoate | US11655243, Example 31 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H40FN3O8S |
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| Mol. Mass. | 621.717 |
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| SMILES | CCC(CC)(NC(=O)c1ccc(N2CC(C2)OS(=O)(=O)c2ccc(C)cc2)c(OC[C@H]2C[C@@H]2CO)n1)C(=O)OCCCF |r| |
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| Structure | 
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