| Reaction Details |
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 | Report a problem with these data |
| Target | Activin receptor type-1 |
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| Ligand | BDBM604682 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical assay |
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| IC50 | <100±n/a nM |
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| Citation |  Kotian, PL; Babu, YS; Kumar, VS; Zhang, W; Lu, P; Raman, K Imidazole-containing inhibitors of ALK2 kinase US Patent US11661426 Publication Date 5/30/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Activin receptor type-1 |
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| Name: | Activin receptor type-1 |
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| Synonyms: | 2.7.11.30 | ACTR-I | ACVR1 | ACVR1_HUMAN | ACVRLK2 | ALK-2 | ALK2/ACVR1 | Activin receptor type I | Activin receptor-like kinase 2 | Activin receptor-like kinase 2 (ALK-2) | Activin receptor-like kinase 2 (ALK2/ACVR1) | Q04771 | SKR1 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I |
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| Type: | n/a |
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| Mol. Mass.: | 57158.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 509 |
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| Sequence: | MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
NPSARLTALRIKKTLTKIDNSLDKLKTDC
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| BDBM604682 |
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| n/a |
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| Name | BDBM604682 |
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| Synonyms: | (S)-(1-(5-fluoro-4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)quinazolin-2-yl)pyrrolidin-2-yl)methanol | US11661426, Compound 341a |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27FN6O4 |
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| Mol. Mass. | 494.5181 |
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| SMILES | COc1cc(cc(OC)c1OC)-n1cnc(Nc2nc(nc3cccc(F)c23)N2CCC[C@H]2CO)c1 |
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| Structure | 
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