| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM349519 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Competitive Radioligand Binding Assay |
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| Ki | 2.10±n/a nM |
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| Citation |  Rishton, GM; Catalano, SM; Look, GC Isoindoline compositions and methods for treating neurodegenerative disease US Patent US11691947 Publication Date 7/4/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
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| Type: | Protein |
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| Mol. Mass.: | 25307.17 |
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| Organism: | Cavia porcellus (Guinea pig) |
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| Description: | Q60492 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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|
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| BDBM349519 |
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| n/a |
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| Name | BDBM349519 |
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| Synonyms: | US10207991, Ex. Cpd. No. 35 | US10611728, Example Compound 35 | US11691947, Example 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21F2N |
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| Mol. Mass. | 301.3735 |
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| SMILES | CC(C)(CCc1ccc(F)cc1)N1Cc2ccc(F)cc2C1 |
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| Structure | 
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