Reaction Details |
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Target | Tumor necrosis factor |
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Ligand | BDBM511470 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Kinase Activity Assay |
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IC50 | 102±n/a nM |
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Citation | deLong, MA; Carlson, E; Kopczynski, C; Sturdivant, JM; Lichorowic, C Isoquinoline-steroid conjugates and uses thereof US Patent US11691950 Publication Date 7/4/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Tumor necrosis factor |
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Name: | Tumor necrosis factor |
Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
Type: | Enzyme |
Mol. Mass.: | 25645.11 |
Organism: | Homo sapiens (Human) |
Description: | P01375 |
Residue: | 233 |
Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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BDBM511470 |
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n/a |
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Name | BDBM511470 |
Synonyms: | US11059789, Example 91 | US11691950, Example 91 |
Type | Small organic molecule |
Emp. Form. | C42H42F2N2O7 |
Mol. Mass. | 724.7889 |
SMILES | C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)c1cccc(c1)[C@@H]1C[C@H]1C(=O)Nc1ccc2cnccc2c1F |r,c:11,t:7| |
Structure |
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