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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Potassium voltage-gated channel subfamily H member 2 | ||
| Ligand | BDBM497142 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | In-Vitro Safety Profile-Testing the Selectivity Over hErg | ||
| Ki | 2500±n/a nM | ||
| Citation |  Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent US11702392 Publication Date 7/18/2023 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Potassium voltage-gated channel subfamily H member 2 | |||
| Name: | Potassium voltage-gated channel subfamily H member 2 | ||
| Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 126672.65 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q12809 | ||
| Residue: | 1159 | ||
| Sequence: |
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| BDBM497142 | |||
| n/a | |||
| Name | BDBM497142 | ||
| Synonyms: | US11001561, Compound 117 | US11702392, Compound 117 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H25Cl2N5O | ||
| Mol. Mass. | 470.394 | ||
| SMILES | Cc1c(nc(N)n(-c2cccc(Cl)c2Cl)c1=O)N1CCC2(Cc3ccccc3[C@H]2N)CC1 |r,wD:28.32,(-1.62,-3.11,;-2.01,-1.62,;-.93,-.53,;-1.32,.95,;-2.81,1.35,;-3.21,2.84,;-3.9,.26,;-5.64,.72,;-6.73,-.37,;-8.22,.03,;-8.62,1.51,;-7.53,2.6,;-7.93,4.09,;-6.04,2.2,;-4.95,3.29,;-3.5,-1.22,;-4.59,-2.31,;.56,-.93,;.96,-2.42,;2.45,-2.82,;3.54,-1.73,;4.13,-3.15,;5.66,-3.03,;6.78,-4.09,;8.26,-3.65,;8.62,-2.15,;7.5,-1.09,;6.02,-1.53,;4.71,-.73,;4.71,.81,;3.14,-.24,;1.65,.16,)| | ||
| Structure | 
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