Ki Summary

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Target

Tyrosine-protein phosphatase non-receptor type 11 [E76Z]

Ligand

BDBM497088

Substrate/Competitor

n/a

Meas. Tech.

SHP2 Biochemical Assay

IC50

3.50±n/a nM

Citation

Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent US11702392 Publication Date 7/18/2023

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein phosphatase non-receptor type 11 [E76Z]

Name:

Tyrosine-protein phosphatase non-receptor type 11 [E76Z]

Synonyms:

n/a

Type:

PROTEIN

Mol. Mass.:

67889.96

Organism:

Homo sapiens

Description:

n/a

Residue:

592

Sequence:

MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLALVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKE
AEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDV
GGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTD
KVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPV
SDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVE
RGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFR
TWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIRE
KGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHE
YTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR

BDBM497088

n/a

Name

BDBM497088

Synonyms:

US11001561, Compound 74a | US11702392, Compound 106

Type

Small organic molecule

Emp. Form.

C25H26Cl2N4O

Mol. Mass.

469.406

SMILES

Cc1nc(N2CCC3(Cc4ccccc4[C@H]3N)CC2)c(C)c(=O)n1-c1cccc(Cl)c1Cl |r,wD:15.17,(-3.34,2.87,;-2.94,1.38,;-1.45,.98,;-1.05,-.51,;.44,-.91,;.83,-2.39,;2.32,-2.79,;3.41,-1.7,;4,-3.13,;5.54,-3,;6.65,-4.06,;8.13,-3.62,;8.49,-2.13,;7.37,-1.07,;5.89,-1.51,;4.58,-.7,;4.58,.84,;3.01,-.22,;1.52,.18,;-2.14,-1.6,;-1.74,-3.08,;-3.63,-1.2,;-4.72,-2.29,;-4.03,.29,;-5.51,.69,;-6.6,-.4,;-8.09,-0,;-8.49,1.49,;-7.4,2.57,;-7.8,4.06,;-5.91,2.18,;-4.82,3.26,)|

Structure