| Reaction Details |
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 | Report a problem with these data |
| Target | Heat shock factor protein 1 |
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| Ligand | BDBM50234074 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cell-Based ELISA (Cellisa) Assay |
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| IC50 | 8.00±n/a nM |
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| Citation |  Jones, K; Rye, C; Chessum, N; Cheeseman, M; Pasqua, AE; Pike, KG; Faulder, PF Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1 US Patent US9701664 Publication Date 7/11/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Heat shock factor protein 1 |
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| Name: | Heat shock factor protein 1 |
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| Synonyms: | HSF1 | HSF1_HUMAN | HSTF1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57244.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1512556 |
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| Residue: | 529 |
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| Sequence: | MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY
SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE
PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR
PPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSP
SVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGS
VDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS
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| BDBM50234074 |
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| n/a |
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| Name | BDBM50234074 |
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| Synonyms: | CHEMBL4070633 | US9701664, Example 39 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H23N3O4 |
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| Mol. Mass. | 453.4892 |
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| SMILES | Cc1ccc2cc(ccc2n1)C(=O)Nc1cc(NC(=O)c2ccc3OCCOc3c2)ccc1C |
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| Structure | 
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