| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 3 |
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| Ligand | BDBM610186 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FLIPR Assay |
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| IC50 | 4.60±n/a nM |
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| Citation |  Caroff, E; Meyer, E Hydroxyalkyl-piperazine derivatives as CXCR3 receptor modulators US Patent US10053457 Publication Date 8/21/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| C-X-C chemokine receptor type 3 |
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| Name: | C-X-C chemokine receptor type 3 |
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| Synonyms: | AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40665.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 368 |
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| Sequence: | MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALY
SLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFG
SGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCL
LFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILA
VLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAK
SVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSET
SEASYSGL
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|
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| BDBM610186 |
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| n/a |
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| Name | BDBM610186 |
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| Synonyms: | 1-{(S)-4-[4-(2-Ethoxy-pyrimidin-5-yl)-2-trifluoromethyl-thiazol-5-yl]-2-hydroxymethyl-piperazin-1-yl}-2-(3-trifluoromethyl-[1,2,4]triazol-1-yl)-ethanone | US10053457, Example 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20F6N8O3S |
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| Mol. Mass. | 566.48 |
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| SMILES | CCOc1ncc(cn1)-c1nc(sc1N1CCN([C@H](CO)C1)C(=O)Cn1cnc(n1)C(F)(F)F)C(F)(F)F |
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| Structure | 
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