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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Monocarboxylate transporter 1 | ||
| Ligand | BDBM345285 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | MCT1-Mediated Lactate Transport in BT20 Breast Cancer Cells (Assay 4) | ||
| IC50 | 42000±n/a nM | ||
| Citation |  Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent US11724989 Publication Date 8/15/2023 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Monocarboxylate transporter 1 | |||
| Name: | Monocarboxylate transporter 1 | ||
| Synonyms: | MCT 1 | MCT1 | MOT1_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | Solute carrier family 16 member 1 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 53956.64 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1451367 | ||
| Residue: | 500 | ||
| Sequence: |
| ||
| BDBM345285 | |||
| n/a | |||
| Name | BDBM345285 | ||
| Synonyms: | 2-[[1-[(2-Isopropylphenyl)methyl]-5-(3- methoxyphenyl)pyrazol-3-yl]methoxy]-2- methyl-propanoic acid. 1HNMR (CDCl3): $#948; 1.13 (s, 3H), 1.15 (s, 3H), 1.55 (s 6H), 2.94-2.97 (m, 1H), 3.62 (s, 3H), 4.63 (s, 2H), 5.42 (s, 2H), 6.39 (s, 1H), 6.65-6.67 (m, 1H), 6.75-6.76 (m, 1H), 6.85-6.91 (m, 2H), 7.07-7.11 (m, 1H), 7.21-7.28 (m, 3H) | US10202350, Example 31 | US10214492, Example 31 | US11292767, Example 31 | US11724989, Example 31 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H30N2O4 | ||
| Mol. Mass. | 422.5167 | ||
| SMILES | COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1C(C)C | ||
| Structure | 
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