| Reaction Details |
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 | Report a problem with these data |
| Target | Monocarboxylate transporter 4 |
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| Ligand | BDBM345302 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells (Assay 3) |
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| IC50 | 89.0±n/a nM |
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| Citation |  Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent US11724989 Publication Date 8/15/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Monocarboxylate transporter 4 |
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| Name: | Monocarboxylate transporter 4 |
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| Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49474.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104604 |
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| Residue: | 465 |
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| Sequence: | MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT
AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV
ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF
LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL
GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF
SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL
LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE
VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
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| BDBM345302 |
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| n/a |
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| Name | BDBM345302 |
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| Synonyms: | 2-([1-[(o-Chlorophenyl)methyl]-5-(m- cyanophenyl)-1H-pyrazol-3-yl]methoxy)- 2-methylpropionic acid 1HNMR (CDCl3): $#948; 1.56 (s, 6H), 4.62 (s, 2H), 5.39 (s, 2H), 6.46 (s, 1H), 6.82-6.84 (m, 1H), 7.18-7.24 (m, 2H), 7.33-7.35 (m 1H), 7.46-7.55 (m, 3H), 7.65-7.68 (m, 1H). | US10202350, Example 48 | US10214492, Example 48 | US11292767, Example 48 | US11724989, Example 48 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20ClN3O3 |
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| Mol. Mass. | 409.866 |
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| SMILES | CC(C)(OCc1cc(-c2cccc(c2)C#N)n(Cc2ccccc2Cl)n1)C(O)=O |
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| Structure | 
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