Reaction Details |
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Target | Poly(ADP-ribose) glycohydrolase |
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Ligand | BDBM616727 |
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Substrate/Competitor | n/a |
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Meas. Tech. | PARG Enzyme Inhibition Assay |
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IC50 | 0.900±n/a nM |
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Citation | XU, Z; LOU, Y; XIE, T; XU, L; CHEN, L; LIU, Y; SUN, Q Compound containing structure of a five-membered heteroaromatic ring, pharmaceutical compositions thereof and applications thereof US Patent US20230278998 Publication Date 9/7/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Poly(ADP-ribose) glycohydrolase |
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Name: | Poly(ADP-ribose) glycohydrolase |
Synonyms: | PARG | PARG_HUMAN | Poly(ADP-ribose) glycohydrolase | poly(ADP-ribose) glycohydrolase (PARG) |
Type: | Protein |
Mol. Mass.: | 111107.13 |
Organism: | Homo sapiens (Human) |
Description: | Q86W56 |
Residue: | 976 |
Sequence: | MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPG
RAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQ
HNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPE
QFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKS
CDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEP
ESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTK
GGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKA
EDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANH
TVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQ
TALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKI
ALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDIN
FNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHV
TYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNEC
LIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEK
MRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYF
TFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAV
ESCAETADHSGQRTGT
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BDBM616727 |
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n/a |
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Name | BDBM616727 |
Synonyms: | US20230278998, Compound 46 |
Type | Small organic molecule |
Emp. Form. | C22H23F2N7O3S2 |
Mol. Mass. | 535.59 |
SMILES | Cn1nc(-c2nnc(s2)C(F)F)c2cc(cc(N3CCC4(COC4)CC3)c12)S(=O)(=O)NC1(CC1)C#N |
Structure |
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