Reaction Details |
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Target | Tyrosine-protein kinase ITK/TSK |
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Ligand | BDBM50587591 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ITK Enzyme Assay |
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IC50 | 16.0±n/a nM |
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Citation | Bagley, SW; Casimiro Garcia, A; Cheng, X; Davoren, JE; Denny, RA; Gerstenberger, BS; Lovering, FE; Parikh, MD; Strohbach, JW; Trujillo, JI Benzimidazole Derivative Compounds and Uses Thereof US Patent US20230280220 Publication Date 9/7/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase ITK/TSK |
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Name: | Tyrosine-protein kinase ITK/TSK |
Synonyms: | EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk |
Type: | Protein |
Mol. Mass.: | 71839.20 |
Organism: | Homo sapiens (Human) |
Description: | Q08881 |
Residue: | 620 |
Sequence: | MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
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BDBM50587591 |
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n/a |
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Name | BDBM50587591 |
Synonyms: | CHEMBL5080834 | US11661419, Example 3 | US20230280220, Example 3 |
Type | Small organic molecule |
Emp. Form. | C25H32N6O2 |
Mol. Mass. | 448.5606 |
SMILES | [H][C@@]12C[C@]1(C)Cc1[nH]nc(-c3nc4cc(N(C)C(=O)[C@@H](C)N5CCOCC5)c(C)cc4[nH]3)c1C2 |r| |
Structure |
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