| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM616908 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Functional Assay of Muscarinic Acetylcholine Receptor Activity |
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| IC50 | 55±n/a nM |
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| Citation |  Xiong, Y; Roppe, J; Chen, AC; Bravo, Y; Schrader, T; Baccei, JM Muscarinic acetylcholine M1 receptor antagonists US Patent US11752149 Publication Date 9/12/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 |
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| Type: | Protein |
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| Mol. Mass.: | 51442.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11229 |
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| Residue: | 460 |
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| Sequence: | MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM616908 |
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| n/a |
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| Name | BDBM616908 |
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| Synonyms: | 6-(3-{3-[(2-methoxypyridin-4- yl)sulfonyl]propanoyl}-3,8- diazabicyclo[3.2.1]octan-8- yl)pyridine-3-carbonitrile | US11752149, Example 15 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23N5O4S |
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| Mol. Mass. | 441.503 |
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| SMILES | COc1cc(ccn1)S(=O)(=O)CCC(=O)N1CC2CCC(C1)N2c1ccc(cn1)C#N |THB:13:15:22:18.19| |
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| Structure | 
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