Ki Summary

Reaction Details

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Target

Interleukin-17F

Ligand

BDBM617582

Substrate/Competitor

n/a

Meas. Tech.

AlphaLISA Assay

IC50

63.1±n/a nM

Citation

MARTIN, BP; WESTERMANN, J; KERN, OT; HOLMES, AJ; MORRISON, A; KICZUN, M; AL MASRI, M; SMITH, A; HUXLEY, A IL-17A MODULATORS US Patent US20230286943 Publication Date 9/14/2023

More Info.:

Get all data from this article, Assay Method

Interleukin-17F

Name:

Interleukin-17F

Synonyms:

Cytokine ML-1 | IL17F | IL17F_HUMAN | il-17f

Type:

Enzyme Catalytic Domain

Mol. Mass.:

18053.35

Organism:

Homo sapiens (Human)

Description:

Q96PD4

Residue:

163

Sequence:

MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIG
IINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNS
VPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ

BDBM617582

n/a

Name

BDBM617582

Synonyms:

US20230286943, Example 50

Type

Small organic molecule

Emp. Form.

C24H30N6O3

Mol. Mass.

450.5334

SMILES

C[C@H]1CC[C@@H](CC1)[C@H](NC(=O)c1conc1C)C(=O)Nc1ccc(cn1)-c1c(C)cnn1C |r,wU:1.0,wD:7.8,4.3,(2,5.9,;2,4.36,;3.33,3.59,;3.33,2.05,;2,1.28,;.67,2.05,;.67,3.59,;2,-.26,;3.33,-1.03,;4.67,-.26,;4.67,1.28,;6,-1.03,;7.41,-.4,;8.44,-1.55,;7.67,-2.88,;6.16,-2.56,;5.02,-3.59,;.67,-1.03,;.67,-2.57,;-.67,-.26,;-2,-1.03,;-2,-2.57,;-3.33,-3.34,;-4.67,-2.57,;-4.67,-1.03,;-3.33,-.26,;-6,-3.34,;-6.16,-4.87,;-5.02,-5.9,;-7.67,-5.19,;-8.44,-3.86,;-7.41,-2.71,;-7.73,-1.21,)|

Structure