Reaction Details |
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Target | Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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Ligand | BDBM618587 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescence Polarization Competition Assay |
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Ki | 557±80 nM |
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Citation | Fletcher, S; Drennen, B Carboxylic acid, acyl sulfonamide and acyl sulfamide-derivatized bicyclic aza-heteroaromatics as selective Mcl-1 inhibitors and as dual Mcl-1/Bcl-2 inhibitors US Patent US11760752 Publication Date 9/19/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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Name: | Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
Synonyms: | B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L) |
Type: | Homodimers/heterodimers with BAX, BAK and BCL2 |
Mol. Mass.: | 26053.63 |
Organism: | Homo sapiens (Human) |
Description: | gi_510901 |
Residue: | 233 |
Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM618587 |
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n/a |
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Name | BDBM618587 |
Synonyms: | US11760752, Compound NB-1-087 |
Type | Small organic molecule |
Emp. Form. | C35H28Cl2N6O6S |
Mol. Mass. | 731.604 |
SMILES | Cc1cc(Oc2ccc(Cn3nc(C(=O)NS(=O)(=O)c4ccc(NCc5cccnc5)c(c4)[N+]([O-])=O)c4cc(Cl)ccc34)cc2)cc(C)c1Cl |
Structure |
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