| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
|---|
| Ligand | BDBM620092 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ATX Enzyme Activity Inhibition Assay |
|---|
| IC50 | 23.0±n/a nM |
|---|
| Citation |  PENG, C; QIAN, M; LV, X; WU, J; YIN, W; LIU, F; JIN, Y; ZOU, G; YUAN, H; WU, ZJ ATX INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF US Patent US20230295159 Publication Date 9/21/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
|---|
| Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
|---|
| Synonyms: | ATX | Autotaxin | Autotaxin (ATX) | E-NPP 2 | ENPP2 | ENPP2_HUMAN | Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP2) | Extracellular lysophospholipase D | LysoPLD | PDNP2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 99007.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13822 |
|---|
| Residue: | 863 |
|---|
| Sequence: | MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCK
GRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHC
SEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDA
TFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHER
PSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQH
FKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNK
VNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYG
RPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVS
PSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVL
VKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQ
PADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFR
KTSRSYPEILTLKTYLHTYESEI
|
|
|
|---|
| BDBM620092 |
|---|
| n/a |
|---|
| Name | BDBM620092 |
|---|
| Synonyms: | 2-(ethyl(2-ethyl-5-(2-morpholinopyrimidin-5-yl)-2H-pyrazolo[4,3-b]pyridin-3-yl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile | US20230295159, Example 29 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H26FN9OS |
|---|
| Mol. Mass. | 555.629 |
|---|
| SMILES | CCN(c1nc(c(s1)C#N)-c1ccc(F)cc1)c1n(CC)nc2ccc(nc12)-c1cnc(nc1)N1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
