| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 6 |
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| Ligand | BDBM621021 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CDK6 Kinase Activity Analysis and Detection Method |
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| IC50 | >1000±n/a nM |
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| Citation |  YANG, P; HAO, H; XIAO, Y; YUAN, K; WANG, X; KUANG, W CDK6/DYRK2 DUAL-TARGET INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF US Patent US20230303553 Publication Date 9/28/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 6 |
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| Name: | Cyclin-dependent kinase 6 |
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| Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 36937.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00534 |
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| Residue: | 326 |
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| Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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| BDBM621021 |
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| n/a |
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| Name | BDBM621021 |
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| Synonyms: | US20230303553, Example 44 | tert-butyl 4-((6-((4-(2-(diethylamino)benzothiazole-6-yl)-5-fluoropyrimidine-2-yl)amino)pyridine-3-yl)methyl)piperazine-1-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C30H37FN8O2S |
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| Mol. Mass. | 592.731 |
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| SMILES | CCN(CC)c1nc2ccc(cc2s1)-c1nc(Nc2ccc(CN3CCN(CC3)C(=O)OC(C)(C)C)cn2)ncc1F |
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| Structure | 
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