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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 1 | ||
| Ligand | BDBM621131 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Inhibitory Assay | ||
| IC50 | 692±n/a nM | ||
| Citation |  HOYT, SB; THOMAS, CJ; FINOCCHIO, CJ; STARCZYNOWSKI, DT; TAWA, GJ; GRACIA MALDONADO, G; ROSEBAUM, JS MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF US Patent US20230303563 Publication Date 9/28/2023 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 1 | |||
| Name: | Interleukin-1 receptor-associated kinase 1 | ||
| Synonyms: | IRAK | IRAK-1 | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 76536.81 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P51617 | ||
| Residue: | 712 | ||
| Sequence: |
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| BDBM621131 | |||
| n/a | |||
| Name | BDBM621131 | ||
| Synonyms: | N-(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)pyridin-2-yl)-6- azaspiro[3.4]octan-2-amine | US20230303563, Compound 183 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H21F2N5 | ||
| Mol. Mass. | 369.411 | ||
| SMILES | FC(F)c1ccc2ncc(-c3cccc(NC4CC5(C4)CCNC5)n3)n2c1 |(-6.48,3.83,;-5.15,3.06,;-5.15,1.52,;-3.81,3.83,;-3.81,5.37,;-2.48,6.14,;-1.14,5.37,;.32,5.85,;1.23,4.6,;.32,3.36,;1.09,2.02,;0,.93,;.4,-.55,;1.89,-.95,;2.98,.14,;4.46,-.26,;5.23,-1.6,;4.14,-2.68,;5.23,-3.77,;6.32,-2.68,;3.99,-4.68,;4.46,-6.14,;6,-6.14,;6.48,-4.68,;2.58,1.62,;-1.14,3.83,;-2.48,3.06,)| | ||
| Structure | 
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