| Reaction Details |
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 | Report a problem with these data |
| Target | LIM domain kinase 1 |
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| Ligand | BDBM622404 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Assay |
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| Ki | 10.6±n/a nM |
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| Citation |  ROUTIER, S; BENEDETTI, H; LÉE-MÉHEUST, B; BONNET, P; PLÉ, K; ACI-SÈCHE, S; RUCHAUD, S; BRAKA, A; CHAMPIRÉ, A; ANDRES, C; VOURC''H, P 4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER US Patent US20230312576 Publication Date 10/5/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| LIM domain kinase 1 |
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| Name: | LIM domain kinase 1 |
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| Synonyms: | LIMK | LIMK-1 | LIMK1 | LIMK1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 72591.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_4505001 |
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| Residue: | 647 |
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| Sequence: | MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS
HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD
GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID
LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID
RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG
LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
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| BDBM622404 |
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| n/a |
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| Name | BDBM622404 |
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| Synonyms: | US20230312576, Compound 40 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H32N6O3 |
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| Mol. Mass. | 524.6135 |
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| SMILES | CC(=O)NCCCOc1cccc(c1)-c1cccc(NC(=O)N2CCC(=CC2)c2ncnc3[nH]cc(C)c23)c1 |c:26| |
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| Structure | 
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