Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | LIM domain kinase 1 |
---|
Ligand | BDBM622485 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | In Vitro Assay |
---|
Ki | 3.08±n/a nM |
---|
Citation | ROUTIER, S; BENEDETTI, H; LÉE-MÉHEUST, B; BONNET, P; PLÉ, K; ACI-SÈCHE, S; RUCHAUD, S; BRAKA, A; CHAMPIRÉ, A; ANDRES, C; VOURC''H, P 4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER US Patent US20230312576 Publication Date 10/5/2023 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
LIM domain kinase 1 |
---|
Name: | LIM domain kinase 1 |
Synonyms: | LIMK | LIMK-1 | LIMK1 | LIMK1_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 72591.81 |
Organism: | Homo sapiens (Human) |
Description: | gi_4505001 |
Residue: | 647 |
Sequence: | MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS
HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD
GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID
LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID
RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG
LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
|
|
|
BDBM622485 |
---|
n/a |
---|
Name | BDBM622485 |
Synonyms: | US20230312576, Compound 198 |
Type | Small organic molecule |
Emp. Form. | C26H25N7O3 |
Mol. Mass. | 483.5218 |
SMILES | CNC(=O)c1cc(Oc2cccc(NC(=O)N3CCC(=CC3)c3ncnc4[nH]cc(C)c34)c2)ccn1 |c:19| |
Structure |
|