| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 |
|---|
| Ligand | BDBM624580 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition of ENPP1 Hydrolysis of 2′,3′-cGAMP |
|---|
| Ki | <3±n/a nM |
|---|
| Citation |  Cogan, DA; Bettigole, S; Van Berkom, L; Nieczypor, P; Su, M; Folmer, R Imino sulfanone inhibitors of ENPP1 US Patent US11780849 Publication Date 10/10/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 |
|---|
| Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 |
|---|
| Synonyms: | ENPP1 | ENPP1_HUMAN | M6S1 | NPPS | PC1 | PDNP1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 104934.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1448940 |
|---|
| Residue: | 925 |
|---|
| Sequence: | MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPL
EKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNC
RCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINY
SSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKK
CGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEW
YKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLP
KDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLIL
ISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSC
REPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNV
FSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVY
TPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYG
RPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPL
SPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTL
LRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKD
TSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSF
YQQRKEPVSDILKLKTHLPTFSQED
|
|
|
|---|
| BDBM624580 |
|---|
| n/a |
|---|
| Name | BDBM624580 |
|---|
| Synonyms: | US11780849, Compound 151 | {2-[1-(6,7-dimethoxycinnolin-4-yl)piperidin- 4-yl]ethyl}(imino)methyl-lambda6-sulfanone |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H26N4O3S |
|---|
| Mol. Mass. | 378.489 |
|---|
| SMILES | COc1cc2nncc(N3CCC(CCS(C)(=N)=O)CC3)c2cc1OC |
|---|
| Structure | 
|
|---|
Search and Browse
