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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] | ||
| Ligand | BDBM624767 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | LRRK2 Wild-Type and G2019S Kinase Activity Assay | ||
| IC50 | 3.70±n/a nM | ||
| Citation |  Jensen, T; Jessing, M; Yu, W; Diaz, DR; Nielsen, J; Jones, CR; Andersen, T; Jacobsen, MF LRRK2 inhibitors US Patent US11780851 Publication Date 10/10/2023 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] | |||
| Name: | Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] | ||
| Synonyms: | LRRK2 | LRRK2 G2019S | LRRK2_HUMAN | Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (G2019S) | Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S) | Leucine-rich repeat serine/threonine-protein kinase 2 G2019S | PARK8 | ||
| Type: | n/a | ||
| Mol. Mass.: | 286143.23 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q5S007(G2019S) | ||
| Residue: | 2527 | ||
| Sequence: |
| ||
| BDBM624767 | |||
| n/a | |||
| Name | BDBM624767 | ||
| Synonyms: | US11780851, Example 37 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H24ClN7O2 | ||
| Mol. Mass. | 417.893 | ||
| SMILES | CO[C@H]1CC[C@@H](CC1)n1nc2OCCCn3nc(Cl)c4cnc(Nc2c1C)nc34 |r,wU:2.1,wD:5.8,(-9.72,-1.27,;-10.01,.24,;-8.84,1.25,;-9.03,2.78,;-7.8,3.71,;-6.38,3.1,;-6.2,1.57,;-7.43,.65,;-5.18,4.07,;-3.71,3.59,;-2.81,4.84,;-1.27,4.84,;-.5,3.5,;.83,2.73,;2.17,3.5,;2.77,4.92,;4.31,4.92,;4.79,6.38,;6.27,6.83,;3.54,7.29,;3.38,8.82,;1.98,9.45,;.73,8.54,;-3.22,7.66,;-3.67,6.19,;-5.18,5.61,;-6.42,6.51,;.89,7.01,;2.3,6.38,)| | ||
| Structure | 
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