| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK [342-635] |
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| Ligand | BDBM311132 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SYK Kinase Inhibition Test |
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| IC50 | 1.80±n/a nM |
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| Citation |  Hoffmann, M; Dahmann, G; Gnamm, C; Fandrick, DR; Scott, J; McCarthy, C Pyrazolyl-substituted heteroaryls and their use as medicaments US Patent US10155751 Publication Date 12/18/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase SYK [342-635] |
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| Name: | Tyrosine-protein kinase SYK [342-635] |
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| Synonyms: | KSYK_HUMAN | SYK | SYK (aa 342-635) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 34105.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43405[342-635] |
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| Residue: | 294 |
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| Sequence: | PMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAV
KILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQ
QNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA
DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV
TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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| BDBM311132 |
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| n/a |
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| Name | BDBM311132 |
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| Synonyms: | US10155751, Example 19 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H29N5O2 |
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| Mol. Mass. | 395.498 |
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| SMILES | CC(C)Cn1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2c(C)n(C)nc2c1 |r| |
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| Structure | 
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