| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 2 |
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| Ligand | BDBM627243 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DGAT2 Enzymatic Activity Assay |
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| IC50 | 21.0±n/a nM |
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| Citation |  Lim, Y; Hugelshofer, CL; Mak, VW; Roane, JP; Sanzone, JR; Shockley, SE; Yen, R Diacylglyceride O-acyltransferase 2 inhibitors US Patent US11787810 Publication Date 10/17/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 2 |
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| Name: | Diacylglycerol O-acyltransferase 2 |
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| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 43848.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96PD7 |
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| Residue: | 388 |
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| Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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| BDBM627243 |
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| n/a |
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| Name | BDBM627243 |
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| Synonyms: | 3-(3-(difluoromethoxy)phenyl)- N-(3-methyl-1,1-dioxidothietan- 3-yl)-1-(2- (trifluoromethyl)tetrahydro-2H- pyran-4-yl)-1H-pyrazolo[4,3- b]pyridine-6-carboxamide (faster eluting in AD-H column, 15% EtOH/CO2) | US11787810, Example 76a | US20240059700, Example 76b |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23F5N4O5S |
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| Mol. Mass. | 574.52 |
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| SMILES | CC1(CS(=O)(=O)C1)NC(=O)c1cnc2c(nn(C3CCO[C@H](C3)C(F)(F)F)c2c1)-c1cccc(OC(F)F)c1 |r| |
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| Structure | 
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