| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal alpha-glucosidase |
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| Ligand | BDBM628489 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of rhGAA Determined by Fluopol-ABPP |
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| Ki | 20000±n/a nM |
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| Citation |  PY, S; KANAZAWA, A; VIEIRA DA CRUZ, A; TANGARA, S NOVEL PHARMACOLOGICAL CHAPERONE COMPOUNDS OF HUMAN ACID ALPHA-GLUCOSIDASE AND THE THERAPEUTIC USE THEREOF US Patent US20230339856 Publication Date 10/26/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal alpha-glucosidase |
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| Name: | Lysosomal alpha-glucosidase |
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| Synonyms: | 70 kDa lysosomal alpha-glucosidase | 76 kDa lysosomal alpha-glucosidase | Acid maltase | Aglucosidase alfa | Alpha glucosidase | GAA | LYAG_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 105312.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1506060 |
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| Residue: | 952 |
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| Sequence: | MGVRHPPCSHRLLAVCALVSLATAALLGHILLHDFLLVPRELSGSSPVLEETHPAHQQGA
SRPGPRDAQAHPGRPRAVPTQCDVPPNSRFDCAPDKAITQEQCEARGCCYIPAKQGLQGA
QMGQPWCFFPPSYPSYKLENLSSSEMGYTATLTRTTPTFFPKDILTLRLDVMMETENRLH
FTIKDPANRRYEVPLETPHVHSRAPSPLYSVEFSEEPFGVIVRRQLDGRVLLNTTVAPLF
FADQFLQLSTSLPSQYITGLAEHLSPLMLSTSWTRITLWNRDLAPTPGANLYGSHPFYLA
LEDGGSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGY
PFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFPLDVQWNDLDYMDSRRDFTFNKDG
FRDFPAMVQELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKV
WPGSTAFPDFTNPTALAWWEDMVAEFHDQVPFDGMWIDMNEPSNFIRGSEDGCPNNELEN
PPYVPGVVGGTLQAATICASSHQFLSTHYNLHNLYGLTEAIASHRALVKARGTRPFVISR
STFAGHGRYAGHWTGDVWSSWEQLASSVPEILQFNLLGVPLVGADVCGFLGNTSEELCVR
WTQLGAFYPFMRNHNSLLSLPQEPYSFSEPAQQAMRKALTLRYALLPHLYTLFHQAHVAG
ETVARPLFLEFPKDSSTWTVDHQLLWGEALLITPVLQAGKAEVTGYFPLGTWYDLQTVPV
EALGSLPPPPAAPREPAIHSEGQWVTLPAPLDTINVHLRAGYIIPLQGPGLTTTESRQQP
MALAVALTKGGEARGELFWDDGESLEVLERGAYTQVIFLARNNTIVNELVRVTSEGAGLQ
LQKVTVLGVATAPQQVLSNGVPVSNFTYSPDTKVLDICVSLLMGEQFLVSWC
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| BDBM628489 |
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| n/a |
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| Name | BDBM628489 |
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| Synonyms: | US20230339856, Compound (IIr) |
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| Type | Small organic molecule |
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| Emp. Form. | C18H31NO4 |
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| Mol. Mass. | 325.443 |
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| SMILES | OC[C@@]1(CCC23CC4CC(CC(C4)C2)C3)NC[C@H](O)[C@@H](O)[C@@H]1O |r,TLB:12:11:14:8.7.6,12:7:14:11.13.10,THB:13:11:8:14.5.6,13:5:8:11.12.10,4:5:8:11.12.10| |
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| Structure | 
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