Ki Summary

Reaction Details

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Target

Myelin transcription factor 1

Ligand

BDBM633114

Substrate/Competitor

n/a

Meas. Tech.

Enzymatic Assay

IC50

3.00±n/a nM

Citation

SZYCHOWSKI, J; LIU, B; DIETRICH, E; PERRYMAN, A; CRANE, SN; TRUONG, VL; ABDOLI, A; BOUCHARD, A QUINAZOLINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME US Patent US20230348456 Publication Date 11/2/2023

More Info.:

Get all data from this article, Assay Method

Myelin transcription factor 1

Name:

Myelin transcription factor 1

Synonyms:

Type:

PROTEIN

Mol. Mass.:

122258.96

Organism:

Homo sapiens (Human)

Description:

ChEMBL_942118

Residue:

1121

Sequence:

MSLENEDKRARTRSKALRGPPETTAADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKR
KLEGAEAEHLVSKRKSHPLKLALDEGYGVDSDGSEDTEVKDASVSDESEGTLEGAEAETS
GQDEIHRPETAEGRSPVKSHFGSNPIGSATASSKGSYSSYQGIIATSLLNLGQIAEETLV
EEDLGQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSL
EDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEE
EEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTHSRK
STVTDESEMQDMMTRGNLGLLEQAIALKAEQVRTVCEPGCPPAEQSQLGLGEPGKAAKPL
DTVRKSYYSKDPSRAEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMH
ENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQPQTGDPSKSSSNSD
RILRPMCFVKQLEVPPYGSYRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRML
APKIQTSETSPKAFQCFDYSQDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKSVD
IEVDENGTLDLSMHKHRKRENAFPSSSSCSSSPGVKSPDASQRHSSTSAPSSSMTSPQSS
QASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVT
LTNFKLKFLSKDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSA
DLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGVKVAPTKDDKEDPELMKCPVPGCVG
LGHISGKYASHRSASGCPLAARRQKEGSLNGSSFSWKSLKNEGPTCPTPGCDGSGHANGS
FLTHRSLSGCPRATFAGKKGKLSGDEVLSPKFKTSDVLENDEEIKQLNQEIRDLNESNSE
MEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIRLPHME
PICEQNFDAYVSTLTDMYSNQDPENKDLLESIKQAVRGIQV

BDBM633114

n/a

Name

BDBM633114

Synonyms:

US20230348456, Compound 135

Type

Small organic molecule

Emp. Form.

C27H24N6O2

Mol. Mass.

464.5185

SMILES

Cc1ccc(O)c(C)c1-c1cc(-c2ccn(n2)C2CC2)c2nc([nH]c(=O)c2c1N)-c1ccncc1 |(2,6.09,;3.33,5.32,;4.67,6.09,;6,5.32,;6,3.78,;7.34,3.01,;4.67,3.01,;4.67,1.47,;3.33,3.78,;2,3.01,;2,1.47,;.67,.7,;.67,-.84,;1.91,-1.75,;1.44,-3.21,;-.1,-3.21,;-.58,-1.75,;-.87,-4.55,;-2.21,-5.32,;-.87,-6.09,;-.67,1.47,;-2,.7,;-3.33,1.47,;-3.33,3.01,;-2,3.78,;-2,5.32,;-.67,3.01,;.67,3.78,;.67,5.32,;-4.67,.7,;-6,1.47,;-7.34,.7,;-7.34,-.84,;-6,-1.61,;-4.67,-.84,)|

Structure