| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK4 |
|---|
| Ligand | BDBM636037 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PLK4 Biochemical Assay |
|---|
| IC50 | 0.802±n/a nM |
|---|
| Citation |  NDUBAKU, C; MOORE, JT; GIBBONS, PA; CHANG, JH; ROMERO, FA; DU, X; KAWAI, H; CIBLAT, S; WANG, H; ALBERT, V; CONSTANTINEAU-FORGET, L; SILVA, H; POLAT, DE; NAYYAR, A; SHORE, DG; WU, K; TAN, J POLO LIKE KINASE 4 INHIBITORS US Patent US20230365537 Publication Date 11/16/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase PLK4 |
|---|
| Name: | Serine/threonine-protein kinase PLK4 |
|---|
| Synonyms: | PLK4 | PLK4_HUMAN | Polo-Like Kinase 4 | SAK | STK18 | Serine/threonine-protein kinase PLK4 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 108996.91 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1474078 |
|---|
| Residue: | 970 |
|---|
| Sequence: | MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNE
VKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQI
ITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISP
EIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKD
LIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSST
SISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRV
IQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKTYTMERCHSAEMLSVSKRSGGGENEERY
SPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWF
GNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQ
NTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLK
PIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLA
DRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPG
ADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICL
ALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMH
SAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWAT
QLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILL
MFSNPTPNFH
|
|
|
|---|
| BDBM636037 |
|---|
| n/a |
|---|
| Name | BDBM636037 |
|---|
| Synonyms: | 6-methoxy-5-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-2-yl]-1H-indazol-3-yl}amino)-N,N-dimethylpyridine-2-carboxamide | US20230365537, Example 166 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H26N6O4 |
|---|
| Mol. Mass. | 498.5331 |
|---|
| SMILES | COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(Nc5ccc(nc5OC)C(=O)N(C)C)n[nH]c4c3)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
