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TargetCell division cycle 7-related protein kinase
LigandBDBM636651
Substrate/Competitorn/a
Meas. Tech.CDC7 Kinase Biochemical Assay
IC50<1±n/a nM
Citation HUANG, X; MONDAL, S; GHANAKOTA, P; BOYLES, N; FRYE, L; LEVINSON, A; GREENWOOD, JR; BOS, P; BHAT, S; GERASYUTO, A; TANG, H HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER US Patent US20230365584 Publication Date 11/16/2023
More Info.:Get all data from this article,  Assay Method
 
Cell division cycle 7-related protein kinase
Name:Cell division cycle 7-related protein kinase
Synonyms:CDC7 | CDC7-related kinase | CDC7L1 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7) | HsCdc7 | huCdc7
Type:Protein
Mol. Mass.:63908.16
Organism:Homo sapiens (Human)
Description:O00311
Residue:574
Sequence:
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI
EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV
KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP
SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG
PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH
ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC
SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD
LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ
GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD
EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM636651
n/a
NameBDBM636651
Synonyms:(R)-5-(2-hydroxybutan-2-yl)- 1-(pyridin-4-yl)-4,6,7,8-tetrahydro- 3H-9-oxa-2-thia-4- azabenzo[cd]azulen-3-one | US20230365584, Compound 72.
TypeSmall organic molecule
Emp. Form.C19H20N2O3S
Mol. Mass.356.439
SMILESCC[C@@](C)(O)c1[nH]c(=O)c2sc(c3OCCCc1c23)-c1ccncc1 |r|
Structure
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