| Reaction Details |
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 | Report a problem with these data |
| Target | Cell division cycle 7-related protein kinase |
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| Ligand | BDBM636658 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CDC7 Kinase Biochemical Assay |
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| IC50 | <1±n/a nM |
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| Citation |  HUANG, X; MONDAL, S; GHANAKOTA, P; BOYLES, N; FRYE, L; LEVINSON, A; GREENWOOD, JR; BOS, P; BHAT, S; GERASYUTO, A; TANG, H HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER US Patent US20230365584 Publication Date 11/16/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cell division cycle 7-related protein kinase |
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| Name: | Cell division cycle 7-related protein kinase |
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| Synonyms: | CDC7 | CDC7-related kinase | CDC7L1 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7) | HsCdc7 | huCdc7 |
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| Type: | Protein |
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| Mol. Mass.: | 63908.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00311 |
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| Residue: | 574 |
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| Sequence: | MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI
EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV
KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP
SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG
PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH
ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC
SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD
LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ
GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD
EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
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| BDBM636658 |
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| n/a |
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| Name | BDBM636658 |
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| Synonyms: | (S)-6-((3-hydroxyazetidin-1- yl)methyl)-4-methyl-2-(1H-pyrazol-4- yl)-5,7-dihydro-3-oxa-1-thia-7- azaacenaphthylen-8(4H)-one | US20230365584, Compound 79. |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18N4O3S |
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| Mol. Mass. | 358.415 |
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| SMILES | C[C@H]1Cc2c(CN3CC(O)C3)[nH]c(=O)c3sc(-c4cn[nH]c4)c(O1)c23 |r| |
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| Structure | 
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