Reaction Details |
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Target | Protein-S-isoprenylcysteine O-methyltransferase |
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Ligand | BDBM637730 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ICMT Biochemical Assay |
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IC50 | 0.640±n/a nM |
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Citation | Ho, SY; Poulsen, A; Tan, SW; Ang, SH; Keller, TH Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase US Patent US11834430 Publication Date 12/5/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Protein-S-isoprenylcysteine O-methyltransferase |
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Name: | Protein-S-isoprenylcysteine O-methyltransferase |
Synonyms: | ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT |
Type: | PROTEIN |
Mol. Mass.: | 31943.26 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_956034 |
Residue: | 284 |
Sequence: | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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BDBM637730 |
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n/a |
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Name | BDBM637730 |
Synonyms: | (R)-3-methoxy-4- ((1-(3-(1-methyl- 1H-pyrazol-5- yl)phenoxy)propan- 2- yl)oxy)benzonitrile | US11834430, Compound 48 |
Type | Small organic molecule |
Emp. Form. | C21H21N3O3 |
Mol. Mass. | 363.4097 |
SMILES | COc1cc(ccc1O[C@H](C)COc1cccc(c1)-c1ccnn1C)C#N |r| |
Structure |
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