| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-S-isoprenylcysteine O-methyltransferase |
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| Ligand | BDBM637734 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ICMT Biochemical Assay |
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| IC50 | 3.60±n/a nM |
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| Citation |  Ho, SY; Poulsen, A; Tan, SW; Ang, SH; Keller, TH Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase US Patent US11834430 Publication Date 12/5/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-S-isoprenylcysteine O-methyltransferase |
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| Name: | Protein-S-isoprenylcysteine O-methyltransferase |
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| Synonyms: | ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31943.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_956034 |
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| Residue: | 284 |
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| Sequence: | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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| BDBM637734 |
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| n/a |
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| Name | BDBM637734 |
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| Synonyms: | 3-amino-4-(2-(3-(2- cyclopropyl-1H- imidazol-1- yl)phenoxy)ethoxy) benzonitrile | US11834430, Compound 52 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N4O2 |
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| Mol. Mass. | 360.4091 |
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| SMILES | Nc1cc(ccc1OCCOc1cccc(c1)-n1ccnc1C1CC1)C#N |
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| Structure | 
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