| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein-S-isoprenylcysteine O-methyltransferase |
|---|
| Ligand | BDBM637758 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ICMT Biochemical Assay |
|---|
| IC50 | 0.390±n/a nM |
|---|
| Citation |  Ho, SY; Poulsen, A; Tan, SW; Ang, SH; Keller, TH Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase US Patent US11834430 Publication Date 12/5/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein-S-isoprenylcysteine O-methyltransferase |
|---|
| Name: | Protein-S-isoprenylcysteine O-methyltransferase |
|---|
| Synonyms: | ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 31943.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_956034 |
|---|
| Residue: | 284 |
|---|
| Sequence: | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
|
|
|
|---|
| BDBM637758 |
|---|
| n/a |
|---|
| Name | BDBM637758 |
|---|
| Synonyms: | 4-(2-((2-(2- cyclopropyl-1H- imidazol-1- yl)pyridin-4- yl)oxy)ethoxy)-3- fluorobenzonitrile | US11834430, Compound 76 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H17FN4O2 |
|---|
| Mol. Mass. | 364.373 |
|---|
| SMILES | Fc1cc(ccc1OCCOc1ccnc(c1)-n1ccnc1C1CC1)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
