Reaction Details |
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Target | Cyclic GMP-AMP synthase |
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Ligand | BDBM639869 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Inhibition Assay |
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IC50 | 4.74±n/a nM |
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Citation | AHMED, A; MARTINEZ BROKAW, C; CARSON, CA; CONNER, SE; FORTNER, KC; FRANCISKOVICH, JB; GERNERT, DL; GREEN, SJ; LUGAR, III, CW; MARIMUTHU, J; NAGARAJAN, S; NICOLAOU, C; ONOBUN, E; STOUT, SL; TROMICZAK, EG; VARIN, T cGAS INHIBITORS US Patent US20230391786 Publication Date 12/7/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Cyclic GMP-AMP synthase |
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Name: | Cyclic GMP-AMP synthase |
Synonyms: | 2.7.7.86 | C6orf150 | CGAS | CGAS_HUMAN | Cyclic GMP-AMP synthase | MB21D1 | Mab-21 domain-containing protein 1 | Synonyms=C6orf150 | cGAMP synthase | h-cGAS |
Type: | PROTEIN |
Mol. Mass.: | 58845.55 |
Organism: | Homo sapiens |
Description: | ChEMBL_117333 |
Residue: | 522 |
Sequence: | MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSR
QKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGS
CRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDIS
TAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLE
EYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKR
KRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLV
PKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQL
KERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKL
ENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
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BDBM639869 |
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n/a |
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Name | BDBM639869 |
Synonyms: | 3-((6,7-Dichloro-2-(hydroxymethyl)-3-(1H-pyrazol-4-yl)-1H-indol-4-yl)oxy)propan-1-ol | US20230391786, Example 338 |
Type | Small organic molecule |
Emp. Form. | C15H15Cl2N3O3 |
Mol. Mass. | 356.204 |
SMILES | OCCCOc1cc(Cl)c(Cl)c2[nH]c(CO)c(-c3cn[nH]c3)c12 |
Structure |
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