| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 2 |
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| Ligand | BDBM504494 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro DGAT2 Assay |
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| IC50 | 42.0±n/a nM |
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| Citation |  Amin, NB; Bergman, AJ; Calle, RA; Dullea, RG; Edmonds, DJ; Esler, WP; Filipski, KJ; Gosset, JR; Kim, AM; Pfefferkorn, JA; Verhoest, PR COMBINATIONS OF DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS AND ACETYL-COA CARBOXYLASE INHIBITOR US Patent US20230405002 Publication Date 12/21/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 2 |
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| Name: | Diacylglycerol O-acyltransferase 2 |
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| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 43848.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96PD7 |
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| Residue: | 388 |
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| Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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| BDBM504494 |
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| n/a |
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| Name | BDBM504494 |
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| Synonyms: | 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin- 3-yl}-N-[(3R,5R)-5-fluoropiperidin-3- yl]pyrimidine-5-carboxamide, trifluoroacetate salt | US11065249, Example 7 | US11471458, Example 7 | US20230405002, Example 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23FN6O3 |
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| Mol. Mass. | 438.4548 |
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| SMILES | CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CNC[C@H](F)C1 |r| |
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| Structure | 
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