Ki Summary

Reaction Details

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Target

Diacylglycerol O-acyltransferase 2

Ligand

BDBM504495

Substrate/Competitor

n/a

Meas. Tech.

In Vitro DGAT2 Assay

IC50

650±n/a nM

Citation

Amin, NB; Bergman, AJ; Calle, RA; Dullea, RG; Edmonds, DJ; Esler, WP; Filipski, KJ; Gosset, JR; Kim, AM; Pfefferkorn, JA; Verhoest, PR COMBINATIONS OF DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS AND ACETYL-COA CARBOXYLASE INHIBITOR US Patent US20230405002 Publication Date 12/21/2023

More Info.:

Get all data from this article, Assay Method

Diacylglycerol O-acyltransferase 2

Name:

Diacylglycerol O-acyltransferase 2

Synonyms:

Type:

Multi-pass membrane protein

Mol. Mass.:

43848.90

Organism:

Homo sapiens (Human)

Description:

Q96PD7

Residue:

388

Sequence:

MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN

BDBM504495

n/a

Name

BDBM504495

Synonyms:

First-eluting isomer (see footnote 4 in Table 1); rac-2-{5-[(3-ethoxypyridin-2- yl)oxy]pyridin-3-yl}-N-[(3R,6S)-6- (trifluoromethyl)piperidin-3- yl]pyrimidine-5-carboxamide or rac-2-{5-[(3-ethoxypyridin-2- yl)oxy]pyridin-3-yl}-N-[(3R,6R)-6- (trifluoromethyl)piperidin-3- yl]pyrimidine-5-carboxamide | US11065249, Example 8 | US11065249, Example 9 | US11471458, Example 9 | US20230405002, Example 11

Type

Small organic molecule

Emp. Form.

C23H23F3N6O3

Mol. Mass.

488.4623

SMILES

CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CC[C@@H](NC1)C(F)(F)F |r|

Structure