| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase II subunit alpha [2-329] |
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| Ligand | BDBM644516 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay for Inhibitors of CK2α Kinase Activity Assay |
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| IC50 | 0.354±n/a nM |
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| Citation |  Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Benzo[c][2,6]naphthyridine derivatives, compositions and therapeutic uses thereof US Patent US11866436 Publication Date 1/9/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase II subunit alpha [2-329] |
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| Name: | Casein kinase II subunit alpha [2-329] |
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| Synonyms: | Casein kinase II subunit alpha (2-329) |
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| Type: | Enzyme |
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| Mol. Mass.: | 39219.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P68400[2-329] |
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| Residue: | 328 |
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| Sequence: | SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN
NEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDF
KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF
YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ
LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL
DKLLRYDHQSRLTAREAMEHPYFYTVVK
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| BDBM644516 |
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| n/a |
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| Name | BDBM644516 |
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| Synonyms: | 5-(2-(4-((3- (cyanomethyl)- 5-(trifluoro- methoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid | US11866436, Example 111 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H27F3N4O5 |
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| Mol. Mass. | 568.5437 |
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| SMILES | OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(CC#N)cc(OC(F)(F)F)c1)c1ccncc21 |
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| Structure | 
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