Ki Summary

Reaction Details

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Target

Mannan-binding lectin serine protease 2

Ligand

BDBM645092

Substrate/Competitor

n/a

Meas. Tech.

Biochemical Human MASP2 Assay

IC50

2.57±n/a nM

Citation

BIERER, D; FLAMME, I; ZUBOV, D; NEUBAUER, T; TERSTEEGEN, A; BAUMANN, L; JUHL, C; GLATZ, M; DREHER, J; HOLTON, S; XIONG, J; XU, J MASP INHIBITORY COMPOUNDS AND USES THEREOF US Patent US20240010684 Publication Date 1/11/2024

More Info.:

Get all data from this article, Assay Method

Mannan-binding lectin serine protease 2

Name:

Mannan-binding lectin serine protease 2

Synonyms:

Type:

PROTEIN

Mol. Mass.:

75689.43

Organism:

Homo sapiens

Description:

ChEMBL_117891

Residue:

686

Sequence:

MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY
FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD
YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC
SALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL
CPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC
PYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPA
CSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTS
SKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLT
AAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNN
KVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTA
AYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNC
GEAGQYGVYTKVINYIPWIENIISDF

BDBM645092

n/a

Name

BDBM645092

Synonyms:

US20240010684, Ex. No 68

Type

Small organic molecule

Emp. Form.

C68H107N17O16S2

Mol. Mass.

1482.811

SMILES

CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](COC)NC(=O)[C@@H]2CSSC(C)(C)[C@H](NC1=O)C(=O)NC(=O)N1CCC[C@H]1C(=O)NCCCCC(=O)Nc1ccc(cc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N2 |r|

Structure