| Reaction Details |
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 | Report a problem with these data |
| Target | Uracil nucleotide/cysteinyl leukotriene receptor |
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| Ligand | BDBM646739 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | GPR17 cAMP Assay Protocol |
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| IC50 | 16.0±n/a nM |
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| Citation |  GALLEY, G; GOBBI, L; GUBA, W; MAZUNIN, D; PINARD, E; RICCI, A PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES US Patent US20240025883 Publication Date 1/25/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Uracil nucleotide/cysteinyl leukotriene receptor |
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| Name: | Uracil nucleotide/cysteinyl leukotriene receptor |
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| Synonyms: | GPR17 | GPR17_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41013.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1353471 |
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| Residue: | 367 |
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| Sequence: | MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENM
LFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHF
SGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLAC
AFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCY
LLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQ
RILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESS
LSAKSEL
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| BDBM646739 |
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| n/a |
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| Name | BDBM646739 |
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| Synonyms: | 6-bromo-N-[5- (cyanomethoxy)-4,6- dimethoxy-pyrimidin-2-yl]-7- fluoro-1H-indole-3- sulfonamide | US20240025883, Example 244 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13BrFN5O5S |
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| Mol. Mass. | 486.272 |
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| SMILES | COc1nc(NS(=O)(=O)c2c[nH]c3c(F)c(Br)ccc23)nc(OC)c1OCC#N |
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| Structure | 
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