| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase SIK3 |
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| Ligand | BDBM647297 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro SIK2 Kinase Assay |
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| IC50 | 38.7±n/a nM |
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| Citation |  Wein, MN; Greenlee, WJ SALT INDUCIBLE KINASE INHIBITORS US Patent US20240025892 Publication Date 1/25/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase SIK3 |
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| Name: | Serine/threonine-protein kinase SIK3 |
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| Synonyms: | 2.7.11.1 | KIAA0999 | QSK | QSK | SIK-3 | SIK3 | SIK3_HUMAN | Salt-inducible kinase 3 | Serine/threonine-protein kinase QSK | Serine/threonine-protein kinase SIK3 | Synonyms=KIAA0999 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 144859.31 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_102770 |
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| Residue: | 1321 |
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| Sequence: | MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMP
ARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKML
CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH
CRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD
GPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVL
DPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDK
EQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTA
MNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVM
EDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLL
NGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEA
VQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQK
MYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTH
QLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQ
QPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAG
QMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSR
GSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYT
RHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFR
HMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPP
HGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLL
GTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPAR
PSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGS
QQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAG
V
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| BDBM647297 |
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| n/a |
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| Name | BDBM647297 |
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| Synonyms: | US20240025892, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29N5O2 |
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| Mol. Mass. | 455.5515 |
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| SMILES | CC1(COc2ccc3n(cnc3c2)-c2ccc3cccc(N4CC5(CC(N)C5)C4)c3n2)COC1 |
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| Structure | 
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