Reaction Details |
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Target | Mitogen-activated protein kinase kinase kinase kinase 1 |
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Ligand | BDBM648147 |
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Substrate/Competitor | n/a |
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Meas. Tech. | HPK1 Kinase Assay (Biochemical Assay) |
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IC50 | <100±n/a nM |
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Citation | TOURE, M; LI, B; NEAGU, C; WANG, Y; JOHNSON, T; UNZUE LOPEZ, A; XIAO, Y; FRIIS, E; DIPOTO, M; GULER, S TETRAHYDROPYRIDO[3,4-d]PYRIMIDINES AS HPK1 INHIBITORS US Patent US20240025922 Publication Date 1/25/2024 |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase kinase kinase kinase 1 |
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Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
Synonyms: | HPK1 | M4K1_HUMAN | MAP4K1 |
Type: | PROTEIN |
Mol. Mass.: | 91316.07 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_586597 |
Residue: | 833 |
Sequence: | MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
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BDBM648147 |
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n/a |
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Name | BDBM648147 |
Synonyms: | US20240025922, Example 115 |
Type | Small organic molecule |
Emp. Form. | C24H28N8O |
Mol. Mass. | 444.5321 |
SMILES | CN1CCc2ncc(Nc3ncc4CCN(Cc4n3)c3cnc4OCCNc4c3C)cc2C1 |
Structure |
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